D-CFAR investigators with primary appointments at WashU, SLU, and HSSU who are either early-stage investigators or more established researchers shifting their focus to HIV are eligible to apply. PIs can submit in collaboration with researchers from other institutions/organizations, but we cannot accept applications directly from researchers outside of WashU, SLU, or HSSU.

We are seeking US-based proposals aligned with the FY 2026–2030 NIH Strategic Plan for HIV and HIV-Related Research. Proposals may address HIV prevention, diagnosis, treatment, cure, or co-occurring conditions at any stage of the Plan's research-to-practice continuum:

1. Fundamental research. This includes HIV biology, immunology, and reservoir dynamics. It also covers the causes and epidemiology of co-occurring conditions, including aging with HIV, and the behavioral, social, and environmental factors that influence HIV outcomes.

2. Preclinical research. This includes new prevention, treatment, and cure candidates. It also covers diagnostics and devices, including technologies for self-testing and multiplex testing.

3. Intervention research. This includes studies of prevention, treatment, cure, and co-occurring conditions. It also covers integrated care models and community-led or co-developed interventions.

4. Implementation research. This covers strategies that improve the reach, uptake, and sustainment of evidence-based HIV prevention, care, and treatment.

Consistent with the Plan's overarching priority, Accelerate implementation science to end the HIV epidemic, implementation science proposals are especially encouraged. Proposals that strengthen HIV research capacity, such as data sharing and harmonization, are also welcome.